Improve Drug Efficiacy
Peptinovo’s targeted drug-delivery platform Peptide-Amphiphile Lipid Micelle (PALM™), safely carries stronger doses of proven approved drugs directly into cancer cells while keeping them away from healthy tissue.
Prevent Interaction with Healthy Tissues
Treatment success is improved, nerve damage is avoided, and healthy tissues are protected. Drugs are modified to look like fats and enclosed in the PALM™ nanoparticle for transport in the bloodstream.
Allow Stronger Doses of Chemotherapy
The drug is released after PALM™ is captured by a fat uptake pathway common to cancer cells but not found in nerves or most healthy tissues. PALM™ is adaptable to a wide variety of proven drugs. The first product is a patented derivative of the world-leading chemotherapy drug paclitaxel.
Peptinovo Aims To
Improve Drug Efficacy
Prevent Interaction with Healthy Tissues
Allow Stronger Doses of Chemotherapy
Improve Drug Efficiacy
Peptinovo’s targeted drug-delivery platform Peptide-Amphiphile Lipid Micelle (PALM™), safely carries stronger doses of proven approved drugs directly into cancer cells while keeping them away from healthy tissue.
Prevent Interaction with Healthy Tissues
Treatment success is improved, nerve damage is avoided, and healthy tissues are protected. Drugs are modified to look like fats and enclosed in the PALM™ nanoparticle for transport in the bloodstream.
Allow Stronger Doses of Chemotherapy
The drug is released after PALM™ is captured by a fat uptake pathway common to cancer cells but not found in nerves or most healthy tissues. PALM™ is adaptable to a wide variety of proven drugs. The first product is a patented derivative of the world-leading chemotherapy drug paclitaxel.
Animal Tests Have Been Completed
The technology was successfully validated in animal studies where paclitaxel in PALM™ (PNB-281) outperformed standard
paclitaxel in tumor reduction while avoiding damage to nerves and other healthy tissues.
Animal Tests Have Been Completed
The technology was successfully validated in animal studies where paclitaxel in PALM™ (PNB-281) outperformed standard
paclitaxel in tumor reduction while avoiding damage to nerves and other healthy tissues.
How It Works
Cancer Cells Use HDL to Grow
PALM™ Looks like HDL to the Cancer Cell
Instead of Building Blocks for Cancer Growth –
PALM™ Delivers Chemotherapy, Causing Cancer Destruction
Cancer Cells Use HDL to Grow
The patented, innovative PALM™ nanotechnology exploits cancer cells’ dependence on cholesterol for tumor growth, by selectively targeting prodrug forms of potent chemotherapy drugs to the cells’ cholesterol-uptake pathway.
PALM Looks like HDL to the Cancer Cell
PALM™ is designed to be a functional and structural mimic of HDL, the natural, bloodborne carrier of cholesterol to cancer cells. Normally, HDL is captured by a receptor and fat transporter that is abundant on cancer cells.
Instead of Building Blocks for Cancer Growth – PALM™ Delivers Chemotherapy, Causing Cancer Destruction
PALM™ is captured by this same receptor to deliver chemotherapy drugs instead. Cancer cells are destroyed. Most healthy tissues lack this receptor and are spared.
How It Works
Cancer Cells Use HDL to Grow
PALM™ Looks like HDL to the Cancer Cell
Instead of Building Blocks for Cancer Growth –
PALM™ Delivers Chemotherapy, Causing Cancer Destruction
Cancer Cells Use HDL to Grow
The patented, innovative PALM™ nanotechnology exploits cancer cells’ dependence on cholesterol for tumor growth, by selectively targeting prodrug forms of potent chemotherapy drugs to the cells’ cholesterol-uptake pathway.
PALM Looks like HDL to the Cancer Cell
PALM™ is designed to be a functional and structural mimic of HDL, the natural, bloodborne carrier of cholesterol to cancer cells. Normally, HDL is captured by a receptor and fat transporter that is abundant on cancer cells.
Instead of Building Blocks for Cancer Growth – PALM™ Delivers Chemotherapy, Causing Cancer Destruction
PALM™ is captured by this same receptor to deliver chemotherapy drugs instead. Cancer cells are destroyed. Most healthy tissues lack this receptor and are spared.
Chemotherapy Drugs are Loaded Into PALM™ as Inactive Prodrugs
Moreover, the chemotherapy drugs are loaded into PALM™ as inactive prodrugs. They do not become active until they are released inside the cancer cell.
Let’s work together to change cancer’s trajectory
We look forward to talking to you. You may contact us for more information.
Enhancing Cancer Survival Rates Through the Development of Intelligent and Targeted Drug Delivery Technologies
Contact Us
Mail: [email protected]
Phone: (734) 306-3228
Peptinovo Biopharma Inc. 600 S Wagner Road Ann Arbor, Michigan 48103
Chemotherapy Drugs are Loaded Into PALM™ as Inactive Prodrugs
Moreover, the chemotherapy drugs are loaded into PALM™ as inactive prodrugs. They do not become active until they are released inside the cancer cell.
Let’s work together to change cancer’s trajectory
We look forward to talking to you. You may contact us for more information.
Enhancing Cancer Survival Rates Through the Development of Intelligent and Targeted Drug Delivery Technologies
Contact Us
Mail:[email protected]
Phone: (734) 306-3228
Peptinovo Biopharma Inc. 600 S Wagner Road Ann Arbor, Michigan 48103